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in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globularhead

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 149-159 doi: 10.1007/s11684-020-0764-y

Abstract: Influenza causes seasonal outbreaks yearly and unpredictable pandemics with high morbidity and mortality rates. Despite significant efforts to address influenza, it remains a major threat to human public health. This issue is partially due to the lack of antiviral drugs with potent antiviral activity and broad reactivity against all influenza virus strains and the rapid emergence of drug-resistant variants. Moreover, designing a universal influenza vaccine that is sufficiently immunogenic to induce universal antibodies is difficult. Some novel epitopes hidden in the hemagglutinin (HA) trimeric interface have been discovered recently, and a number of antibodies targeting these epitopes have been found to be capable of neutralizing a broad range of influenza isolates. These findings may have important implications for the development of universal influenza vaccines and antiviral drugs. In this review, we focused on the antibodies targeting these newly discovered epitopes in the HA domain of the influenza virus to promote the development of universal anti-influenza antibodies or vaccines and extend the discovery to other viruses with similar conformational changes in envelope proteins.

Keywords： influenza virus     neutralizing antibody     hemagglutinin     globular head region     trimeric interface    

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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 130-136 doi: 10.15302/J-FASE-2014013

Abstract: this study, using real-time quantitative RT-PCR, we investigated the expression pattern of and its head-to-headThese results indicate that the head-to-head genes of and exhibit similar expression in chicken follicles

Keywords： chicken     Vps36     Ckap2     mRNA     follicle    

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Basic consideration of research strategies for head and neck cancer

Jin Gao, Ben Panizza, Newell W. Johnson, Scott Coman, Alan R. Clough

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 339-353 doi: 10.1007/s11684-012-0213-7

Abstract:

Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomicalaims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head

Keywords： clinical management     head and neck cancer     prevention and early detection     research strategies     risk factors    

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Influence of surface cracking, anchor head profile, and anchor head size on cast-in headed anchors in

Frontiers of Structural and Civil Engineering   Pages 1163-1187 doi: 10.1007/s11709-023-0987-5

Abstract: of the above prediction models depends on the effective embedment depth of the anchor and the anchor headThe influence of the anchor head profile on the tensile capacity of the anchors is found to be insignificant

Keywords： cast-in anchor     concrete cone capacity     geopolymer concrete     head size     surface crack     anchor profile    

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factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head

Yutao Liu, Yaxia Di, Shuai Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 239-246 doi: 10.1007/s11684-017-0509-8

Abstract:

Patients undergoing major oncological surgery for head and neck cancer (SHNC) have a particularly

Keywords： ventilator-associated pneumonia (VAP)     pneumonia     risk factors     surgery for head and neck cancer (SHNC)    

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Model test study for ice force on the bank-head of the lead-navigating bank

SONG An, SUN Jinliang, LU Hai, WANG Yi′an

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2,   Pages 222-228 doi: 10.1007/s11709-007-0027-x

Abstract: To determine the bank-head s ice force of the lead-navigating bank at key position that faces the icevelocity on the ice force , ratio of components of forces when ice sheet acting on the vertical bank-head

Keywords： comparison     lead-navigating bank     vertical bank-head     certain     Preliminary    

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Biologically inspired model of path integration based on head direction cells and grid cells

Yang ZHOU,De-wei WU

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 5,   Pages 435-448 doi: 10.1631/FITEE.1500364

Abstract: The firing of head direction cells (HDCs) and grid cells (GCs) is related to the moving direction and

Keywords： Head direction cells (HDCs)     Grid cells (GCs)     Path integration     Bionic navigation    

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Ultramicrostructure and clinical implications of satellite foci in front of the head of pterygium

LIU Haixia, XIANG Nan, ZHOU Xiongwu, HU Weikun, LI Guigang, ZHANG Hong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 211-214 doi: 10.1007/s11684-007-0040-4

Abstract: In our previous studies, grey satellite foci were found in the front of heads of pterygia. This research was designed to investigate the ultramicrostructure and clinical implications of these satellite foci. The satellite foci were observed and counted under slit lamp biomicroscope. The patients with eye pterygia were divided into groups in terms of occupation, sex, age, length of history, grade of congestion, and size of the heads. The SPSS 13.0 software was used for statistical analysis. The cap areas and satellite foci were ultramicrostructurally examined. Among the total 62 eyes with pterygium, satellite foci were found in 34. The overall incidence of satellite foci was 54.8%. There were no significant differences in incidence among the subjects of different sex, age, and length of history. There were significant differences in incidence among the patients of different occupation, grades of congestion, and size of heads. Higher grades of congestion, outdoor occupations and larger pterygium heads were associated with higher incidence of satellite foci. High grades of congestion and bigger heads were also correlated with the number of satellite foci. Length of history bore no correlation with number of satellite foci. Histologically, the components of the cap areas and the foci were identical, with both consisting of mass of active fibroblasts. The activated fibroblasts existed in the natural tissue planes between Bowman s layer and basal cell layer. The fibroblasts in the satellite foci and the cap areas of a pterygium show some features of tumor cells and may play a vital role in the development and progression of a pterygium. The presence and amount of satellite foci around a pterygium can be used as an indicator for the speed of its growth.
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Three New Missions Head for Mars

Mitch Leslie

Engineering 2020, Volume 6, Issue 12,   Pages 1336-1338 doi: 10.1016/j.eng.2020.10.007

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The comparative study of dwelling houses in the southwest multi-ethnic region, taking Fugong county for

Fang WANG, Jiaping LIU

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 4,   Pages 474-482 doi: 10.1007/s11709-010-0089-z

Abstract: A number of ethnic minorities are being distributed in southwest China. Yunnan Province is an area inhabited by multi-ethnic groups. For a long time, the ethnic groups have been interacted by others in the cultural aspect, while retaining their own ethnic traditions. The performances of ethnic groups’ dwelling houses are similar as determined by natural and cultural elements of the same area. This paper mainly analyzes decisive factors behind similar appearances by the way of field research on two minorities, Nu ethnic group and Li-su ethnic group, in the Fugong county, Nujiang Li-su autonomous prefecture. Moreover, the paper tries to summarize the commonality and individuality of the minorities in order to provide useful theoretical reference for the minorities building of new socialist countryside in the future.

Keywords： Nu ethnic group     Li-su ethnic group     mixed region     living culture     living mode     living acts    

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Genomic Sequencing Costs Set to Head Down Again

Robert Pollie

Engineering 2023, Volume 23, Issue 4,   Pages 3-6 doi: 10.1016/j.eng.2023.02.002

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Research and Improvement of the Pipe Space Curve of High-speed Laying Head

Liu Hongmin,Yao Shuangji,Yang Lipo,Pang Zhifeng,Li Shuanglai,Liu Wubin,Yan Shengyou,Chu Jiandong

Strategic Study of CAE 2006, Volume 8, Issue 11,   Pages 80-85

Abstract:

For the working problems of laying head of high speed wire rod, choosing cubic spline function tomodel is used to analyze the state of the wire rod and research the curve´s effect on the laying headsome improvement on the space curve and bending processing of the pipe, the working state of laying head

Keywords： high speed laying head     pipe of loop laying head     space curve    

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Research Status and Trends of Ultra-Low-Head Water Resources and Hydro-Turbines

Zhang Yuquan,Zheng Yuan,Sun Ke,Yang Chunxia and Luo Hongying

Strategic Study of CAE 2018, Volume 20, Issue 3,   Pages 90-95 doi: 10.15302/J-SSCAE-2018.03.013

Abstract:

China is rich in hydropower resources, and hydropower technology development is the first choice to increase the supply of renewable energy, optimize the energy structure, and alleviate environmental problems. This paper focuses on rich microhead resources in China and presents the demand and application characteristics of microhead resources such as rivers, canals, reservoirs, power plant tailings, piped water supply, municipal wastewater, and marine energy. The paper summarizes two types of microhead hydro-turbines suitable for open and closed watersheds, which provide a basis for the design method of microhead hydro-turbines and the study of their flow characteristics and mechanism. This paper introduces the research trend of microhead resource evaluation and hydropower turbines. In addition, some suggestions for future research are put forward.

Keywords： ultra-low-head water resources     hydro-turbines     open watershed     closed watershed    

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Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 418-422 doi: 10.1007/s11684-007-0082-7

Abstract: The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion werememorizing, Nissl staining was used to count the average number of survived neurons in hippocampal CA1 regionCompared with normal group, the expression of MAP-2 in hippocampal CA1 region obviously decreased in
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Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 12, doi: 10.1007/s11783-022-1593-9

Abstract:

● The airborne bacteria in landfills were 4–50 times higher than fungi.

Keywords： Microbial aerosols     Landfill sites     Health risk assessment     CALPUFF    

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Title Author Date Type Operation

in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globularhead

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Journal Article

Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Journal Article

Basic consideration of research strategies for head and neck cancer

Jin Gao, Ben Panizza, Newell W. Johnson, Scott Coman, Alan R. Clough

Journal Article

Influence of surface cracking, anchor head profile, and anchor head size on cast-in headed anchors in

Journal Article

factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head

Yutao Liu, Yaxia Di, Shuai Fu

Journal Article

Model test study for ice force on the bank-head of the lead-navigating bank

SONG An, SUN Jinliang, LU Hai, WANG Yi′an

Journal Article

Biologically inspired model of path integration based on head direction cells and grid cells

Yang ZHOU,De-wei WU

Journal Article

Ultramicrostructure and clinical implications of satellite foci in front of the head of pterygium

LIU Haixia, XIANG Nan, ZHOU Xiongwu, HU Weikun, LI Guigang, ZHANG Hong

Journal Article

Three New Missions Head for Mars

Mitch Leslie

Journal Article

The comparative study of dwelling houses in the southwest multi-ethnic region, taking Fugong county for

Fang WANG, Jiaping LIU

Journal Article

Genomic Sequencing Costs Set to Head Down Again

Robert Pollie

Journal Article

Research and Improvement of the Pipe Space Curve of High-speed Laying Head

Liu Hongmin,Yao Shuangji,Yang Lipo,Pang Zhifeng,Li Shuanglai,Liu Wubin,Yan Shengyou,Chu Jiandong

Journal Article

Research Status and Trends of Ultra-Low-Head Water Resources and Hydro-Turbines

Zhang Yuquan,Zheng Yuan,Sun Ke,Yang Chunxia and Luo Hongying

Journal Article

Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Journal Article

Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

Journal Article